发明名称 |
WAP domain fusion polypeptides and methods of use thereof |
摘要 |
This invention relates to fusion proteins that include a whey acidic protein (WAP) domain-containing polypeptide and a second polypeptide. Additionally, the invention relates to fusion proteins that include a WAP domain-containing polypeptide, a second polypeptide, and a third polypeptide. The second and/or third polypeptides of the fusion proteins of the invention are an Fc polypeptide; an albumin polypeptide; a cytokine targeting polypeptide; or a serpin polypeptide. This invention also relates to methods of using such molecules in a variety of therapeutic and diagnostic indications, as well as methods of producing such molecules. |
申请公布号 |
AU2012275295(B2) |
申请公布日期 |
2016.11.10 |
申请号 |
AU20120275295 |
申请日期 |
2012.06.28 |
申请人 |
Inhibrx LLC |
发明人 |
Timmer, John C.;Eckelman, Brendan P.;Guenther, Grant B.;Nguy, Peter L.;Chan, Henry;Deveraux, Quinn |
分类号 |
C07K19/00;A61K39/395;C12P21/08 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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