| 发明名称 |
COVALENTLY LINKED POLYPEPTIDE TOXIN-ANTIBODY CONJUGATES |
| 摘要 |
Herein is reported a conjugate of a haptenylated polypeptide toxin and an anti-hapten antibody, wherein a disulfide bond is formed between a cysteine residue either before or after the lysine residue that is used for hapten-conjugation and a cysteine residue in the CDR2 of the antibody, whereby the CDR2 is determined according to Kabat. |
| 申请公布号 |
EP3089759(A1) |
申请公布日期 |
2016.11.09 |
| 申请号 |
EP20140825155 |
申请日期 |
2014.12.29 |
| 申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
BRINKMANN, ULRICH;HOFFMANN, EIKE;DENGL, STEFAN;MAYER, KLAUS |
| 分类号 |
A61K47/48;A61P35/00;C07K16/44 |
主分类号 |
A61K47/48 |
| 代理机构 |
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