| 摘要 |
A microparticle which comprises an acid with two or more acid groups and an organic base. The microparticle may have a particle size of 0.5-10 microns, and a molar ratio of acid groups to basic groups of 0.6-1.4:1. The acid may comprise bis-aliphatic acid, brassylic acid, sebacic acid, azelaic acid or a bis-carboxylic fatty acid in which the terminal carboxylic acids are linked by a region which is hydrophobic. The acid groups may also be separated by a saturated or unsaturated aliphatic chain; or substituted saturated, or unsaturated aliphatic chain. The organic base may comprise an aliphatic amine or an aromatic amine having a basic character or other nitrogen-containing base, one or more of an alkylated amine and an alkylated polyamine, N-methylmorpholine, N,N-dimethylaminoethanol, 4-dimethylaminopyridine, imidazole, 1-methylamidazole poly(diallyldimethylammonium chloride) (PDAC), didecylmethylammonium chloride (DDAC), dodecyldipropylenetriamine (DDPT) and poly epsilon lysine. A medical diagnostic, monolith and use of the self-assembled microparticles are also disclosed. |
