METHOD FOR PREPARING HYDROXYPROPYL METHYLCELLULOSE ACETATE SUCCINATE (HPMCAS) GRAINS HAVING CONTROLLED GRAIN SIZE DISTRIBUTION, AND HPMCAS POWDER
摘要
Disclosed are a method for preparing hydroxypropyl methylcellulose acetate succinate (HPMCAS) grains and HPMCAS grains. The disclosed method for preparing HPMCAS grains comprises: a step of esterifying hydroxypropyl methylcellulose (HPMC), acetic anhydride, and succinic anhydride in a reaction medium in the presence of a catalyst so as to obtain a reaction solution containing HPMCAS (esterification step); and a step of continuously or intermittently putting the reaction solution into water so as to form grains (granulating step).
申请公布号
EP3091036(A1)
申请公布日期
2016.11.09
申请号
EP20140877031
申请日期
2014.12.15
申请人
LOTTE FINE CHEMICAL CO., LTD.
发明人
BANG, SUNG HWAN;SHIN, JU HEE;SON, JIN RYUL;PARK, KYUNG YEOL;CHUN, JEONG HEE;JEONG, JI SEON;LEE, SANG YOUB