炎症性ヒトＴｈ１７細胞の増殖および機能を決定的に調節するＩＣＯＳ

摘要

The invention includes compositions and methods for generating and expanding therapeutic Th17 cells. The invention includes contacting T cells with a composition comprising a first agent that is capable of providing a primary activation signal to T cells and a second agent that is capable of activating ICOS on T cells in the presence of Th-17 polarizing agents.