发明名称 |
HETEROATOM CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS |
摘要 |
Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions in a method of treating cancer. The dUTPase inhibitors disclosed contain a uracil isostere in the molecule represented by a 2,6-diketopiperazine moiety. Thioanalogs of the uracil isostere where a thione replaces each of the ketone are also disclosed. |
申请公布号 |
EP3089964(A1) |
申请公布日期 |
2016.11.09 |
申请号 |
EP20150733304 |
申请日期 |
2015.01.02 |
申请人 |
UNIVERSITY OF SOUTHERN CALIFORNIA |
发明人 |
LADNER, ROBERT D.;GIETHLEN, BRUNO |
分类号 |
C07D241/08;C07D241/18;C07D403/12 |
主分类号 |
C07D241/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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