发明名称 |
HUMAN ANTI-IL-33 NEUTRALIZING MONOCLONAL ANTIBODY |
摘要 |
An object of the present invention is to provide an antibody having antagonistic effect against IL-33, in particular an isolated human anti-IL-33 neutralizing monoclonal antibody wherein amino acid sequences of framework regions are amino acid sequences that are amino acid sequences from a germline or a combination of amino acid sequences thereof" or a fragment thereof. The epitopes for a plurality of anti-IL-33 monoclonal antibodies were identified, human anti-IL-33 neutralizing monoclonal antibodies were obtained, and the complementarity-determining regions that achieve high binding ability to IL-33 was specified by introducing mutations in the complementarity-determining regions. The identified complementarity-determining regions were used to produce a human anti-IL-33 neutralizing monoclonal antibody having framework regions comprising amino acid sequences that are amino acid sequences of a germline or a combination of amino acid sequences thereof. |
申请公布号 |
EP3088517(A1) |
申请公布日期 |
2016.11.02 |
申请号 |
EP20140873812 |
申请日期 |
2014.12.26 |
申请人 |
MITSUBISHI TANABE PHARMA CORPORATION |
发明人 |
FUJINO, YASUHIRO;YOSHIKAWA, TSUTOMU;OCHI, HIROSHI |
分类号 |
C12N15/09;A61K39/395;A61P1/04;A61P11/00;A61P11/06;A61P13/12;A61P17/00;A61P17/04;A61P19/02;A61P21/02;A61P29/00;A61P37/06;A61P43/00;C07K7/08;C07K14/54;C07K16/24 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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