发明名称 |
1,5-NAPHTHYRIDINE DERIVATIVE OR SALT THEREOF |
摘要 |
A 1,5-naphthyridine derivative represented by Formula [1] (in which R 1 , R 2 , R 3 , R 4 and R 5 represent a hydrogen atom, -L-Z (in which Z represents a non-aromatic heterocyclic group or the like; and L represents a single bond or the like), or the like, R 6 represents -L-Z or the like, R 7 and R 8 represent a hydrogen atom or the like, and Q represents an oxygen atom or the like), or a salt thereof has an excellent inhibitory activity with respect to the PI3K-AKT pathway and the Ras-Raf-MEK-ERK pathway, and is useful for treatments such as prophylactic treatments and therapeutic treatments of diseases in which the PI3K-AKT pathway and the Ras-Raf-MEK-ERK pathway are involved. |
申请公布号 |
EP2727920(B1) |
申请公布日期 |
2016.11.02 |
申请号 |
EP20120819498 |
申请日期 |
2012.07.27 |
申请人 |
FUJIFILM CORPORATION |
发明人 |
FURUYAMA, HIDETOMO;KURIHARA, HIDEKI;FURUYA, KENTAROU;TERAO, TAKAHIRO;SEKINE, SHINICHIROU;NAKAGAWA, DAISUKE |
分类号 |
C07D471/04;A61K31/4375;A61K31/444;A61K31/4709;A61K31/496;A61K31/5377;A61P5/00;A61P9/00;A61P25/00;A61P29/00;A61P31/00;A61P35/00;A61P37/06;A61P37/08;A61P43/00;C07D519/00 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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