发明名称 |
N-SUBSTITUTED IMIDAZOLE CARBOXYLIC ESTER CHIRAL COMPOUND CONTAINING ETHER SIDE CHAIN, PREPARATION METHOD AND APPLICATION |
摘要 |
The present invention relates to an N-substituted imidazole carboxylic ester chiral compound containing an ether side chain and to its preparation and application. The structure of this compound is represented by Formula (I). This compound can induce a rapid and reversible general anesthesia effect. Animal experiments show that this compound has rapid and short-acting pharmacological characteristics, so that it can be used as a rapid and short-acting general anesthesia medicine. Compared with etomidate, this compound can reduce the inhibition on the synthesis of adrenal cortical hormone, with an advantage of rapid and full recovery of the post-operative patient. The only chiral carbon in the compound structure belongs to the R form. This imidazole ring in the compound structure has acidifiable N atoms, so that this compound or its related pharmaceutically-acceptable salts can be used in preparation of the central inhibitory medicines, which can produce sedative, hypnotic and/or anesthetic effects on animals or human beings via their intravenous or non-intravenous administration. |
申请公布号 |
EP3088394(A1) |
申请公布日期 |
2016.11.02 |
申请号 |
EP20140873468 |
申请日期 |
2014.10.30 |
申请人 |
WEST CHINA HOSPITAL, SICHUAN UNIVERSITY |
发明人 |
ZHANG, WENSHENG;YANG, JUN;LIU, JIN;TANG, LEI;KE, BOWEN |
分类号 |
C07D233/90;A61P23/00;A61P25/20 |
主分类号 |
C07D233/90 |
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