发明名称 |
SUBSTITUTED PURINE NUCLEOSIDES, PHOSPHOROAMIDATE AND PHOSPHORODIAMIDATE DERIVATIVES FOR TREATMENT OF VIRAL INFECTIONS |
摘要 |
This invention is directed to phosphoroamidate and phosphorodiamidate derivatives including the compounds of formula (I) having the structure wherein U, V, W, Z, R1, X1, X2, and Y are defined herein. These compounds and pharmaceutical compositions containing these compounds are useful in the treatment of viral infections in mammals infected by a virus in the Flaviviridae family of viruses, in particular hepatitis C virus (HCV). The compounds of this invention may be prepared by various methods known in the art of organic chemistry in general and nucleoside and nucleotide analog synthesis in particular. |
申请公布号 |
EP2658857(B1) |
申请公布日期 |
2016.11.02 |
申请号 |
EP20110852610 |
申请日期 |
2011.12.29 |
申请人 |
INHIBITEX, INC.;UNIVERSITY COLLEGE CARDIFF CONSULTANTS, LTD. |
发明人 |
MCGUIGAN, CHRISTOPHER;MADELA, KAROLINA;BOURDIN, CLAIRE;VERNACHIO, JOHN;CHAMBERLAIN, STANLEY |
分类号 |
C07H19/067;A61K31/7076;A61K31/708;A61P31/12 |
主分类号 |
C07H19/067 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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