发明名称 |
METHODS AND INTERMEDIATES FOR THE PREPARATION OF (4BS,5AR)-12-CYCLOHEXYL-N-(N,N-DIMETHYLSULFAMOYL)-3- METHOXY-5A-((1R,5S)-3-METHYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBONYL)-4B,5,5A,6-TETRAHYDROBENZO [3,4]CYCLOPROPA[5,6]AZEPINO[1,2-A]INDOLE-9-CARBOXAMIDE |
摘要 |
The present invention provides methods and intermediates for the preparation of (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide (formula I), including pharmaceutically acceptable salts. The compound has activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV. |
申请公布号 |
EP2875030(B1) |
申请公布日期 |
2016.10.26 |
申请号 |
EP20130740485 |
申请日期 |
2013.07.16 |
申请人 |
BRISTOL-MYERS SQUIBB HOLDINGS IRELAND |
发明人 |
DELMONTE, ALBERT J.;NATALIE, JR., KENNETH J.;FRAUNHOFFER, KENNETH J.;RISATTI, CHRISTINA ANN;HANG, CHAO;GAO, ZHINONG;DAVULCU, AKIN H.;HU, WENHAO |
分类号 |
C07D519/00;A61K31/55;A61P31/14;C07D487/04 |
主分类号 |
C07D519/00 |
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