发明名称 |
CANCER IMMUNOTHERAPY BY DELIVERING CLASS II MHC ANTIGENS USING A VLP-REPLICON |
摘要 |
Described herein is a method of preventing or treating a disease in a mammalian subject, comprising administering to the subject who is in need thereof an effective dosage of a pharmaceutical composition comprising a virus like particle (VLP) comprising: an alphavirus replicon comprising a recombinant polynucleotide, wherein the polynucleotide comprises a sequence encoding both subunits of a human class II major histocompatibility antigen, a retroviral gag protein, and a fusogenic envelope protein, wherein the VLP does not contain an alphavirus structural protein gene. |
申请公布号 |
EP3082851(A2) |
申请公布日期 |
2016.10.26 |
申请号 |
EP20140824680 |
申请日期 |
2014.12.16 |
申请人 |
THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
CHATTERJEE, DEB, K;KACZMARCZYK, STANISLAW, J. |
分类号 |
A61K39/00;A61K39/12;C12N7/01;C12N15/86 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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