发明名称 |
SYSNTHESIS OF OXYCODONE HYDROCHLORIDE |
摘要 |
Synthetic methods are provided for preparation of oxycodone and salts thereof with an improved impurity profile. Thebaine is converted to 14-hydroxycodeinone sulfate intermediate to minimize a 7,8-dihydro-8,14-dihydroxycodeinone impurity. Efficient methods for conversion of oxycodone base to oxycodone hydrochloride are provided to minimize 14-hydroxycodeinone impurity in the final product. |
申请公布号 |
EP3083632(A2) |
申请公布日期 |
2016.10.26 |
申请号 |
EP20140824727 |
申请日期 |
2014.12.18 |
申请人 |
CODY LABORATORIES, INC. |
发明人 |
ITOV, ZINOVY;KUZNETSOV, VLADIMIR, F.;VOITSEKHOVSKI, IOURI |
分类号 |
C07D489/08 |
主分类号 |
C07D489/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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