HETERODIMERIC NUCLEAR RECEPTORS PROTEINS, GENES ENCODING SAME, AND USAGE THEREOF

摘要

2106382 9315216 PCTABS00024 The present invention is based in part on the novel observation that two different types of nuclear receptors, retinoic acid receptors (RAR) and thyroid receptors (TR) dimerize with an RX receptor (RXR) to form a heterodimer which is capable of binding to retinoic acid response elements (RARE) or thyroid receptor response elements (TRE) at physiological conditions. Based on this observation, the present invention provides novel heterodimeric proteins, methods of identifying agents capable of binding the heterodimers of the present invention, methods of identifying DNA sequences capable of being bound by the heterodimers and methods to identify RA metabolic enzymes and proteins which are required for the activation function of nuclear receptors.