| 发明名称 |
IGG4 ANTIBODY VARIANTS HAVING MODIFICATIONS IN THE CONSTANT REGION |
| 摘要 |
The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of lgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed. |
| 申请公布号 |
EP2373687(B1) |
申请公布日期 |
2016.10.26 |
| 申请号 |
EP20090771325 |
申请日期 |
2009.12.03 |
| 申请人 |
GENMAB A/S |
发明人 |
LABRIJN, ARAN FRANK;LOVERIX, STEFAN;PARREN, PAUL;VAN DE WINKEL, JAN;SCHUURMAN, JANINE;LASTERS, IGNACE |
| 分类号 |
C07K16/00;A61K39/00;A61K39/395;A61K47/48;A61K51/10;C07K16/28 |
主分类号 |
C07K16/00 |
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