GENE SIGNATURE BIOMARKERS OF TUMOR RESPONSE TO PD-1 ANTAGONISTS
摘要
The present disclosure describes gene signature biomarkers that are useful for identifying cancer patients who are most likely to benefit from treatment with a PD-1 antagonist. The disclosure also provides methods and kits for testing tumor samples for the biomarkers, as well as methods for treating subjects with a PD-1 antagonist based on the test results.
申请公布号
EP3084001(A2)
申请公布日期
2016.10.26
申请号
EP20140871078
申请日期
2014.12.15
申请人
MERCK SHARP & DOHME CORP.
发明人
AYERS, MARK;LOBODA, ANDREY;LUNCEFORD, JARED;MCCLANAHAN, TERRILL, K.;MURPHY, ERIN;NEBOZHYN, MICHAEL;PIERCE, ROBERT, H.