发明名称 |
METHOD FOR INHIBITING BONE RESORPTION |
摘要 |
The invention is directed to a method of inhibiting bone resorption. The method comprises administering to a human an amount of sclerostin inhibitor that reduces a bone resorption marker level for at least 2 weeks. The invention also provides a method of monitoring anti-sclerostin therapy comprising measuring one or more bone resorption marker levels, administering a sclerostin binding agent, then measuring the bone resorption marker levels. Also provided is a method of increasing bone mineral density; a method of ameliorating the effects of an osteoclast-related disorder; a method of treating a bone-related disorder by maintaining bone density; and a method of treating a bone-related disorder in a human suffering from or at risk of hypocalcemia or hypercalcemia, a human in which treatment with a parathyroid hormone or analog thereof is contraindicated, or a human in which treatment with a bisphosphonate is contraindicated. |
申请公布号 |
EP3085386(A1) |
申请公布日期 |
2016.10.26 |
申请号 |
EP20160162068 |
申请日期 |
2008.09.17 |
申请人 |
AMGEN INC. |
发明人 |
PADHI, IAN DESMOND;JANG, GRAHAM RICHARD |
分类号 |
A61K39/395;A61K39/00;A61P19/08;C07K16/18 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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