| 发明名称 |
USE OF PEPTIDYLGLYCINE ALPHA-AMIDATING MONOOXIGENASE (PAM) FOR C-TERMINAL AMIDATION |
| 摘要 |
One aspect as reported herein is a method for in vivo C-terminal amidation of a polypeptide characterized in that both the polypeptide (to be amidated) and human peptidylglycine alpha-amidating monooxigenase (PAM) are recombinantly co-expressed in a mammalian cell. |
| 申请公布号 |
EP3083662(A1) |
申请公布日期 |
2016.10.26 |
| 申请号 |
EP20140811848 |
申请日期 |
2014.12.10 |
| 申请人 |
F.HOFFMANN-LA ROCHE AG |
发明人 |
HOFFMANN, EIKE;TIEFENTHALER, GEORG |
| 分类号 |
C07K14/435 |
主分类号 |
C07K14/435 |
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