Described herein are chimeric Newcastle disease viruses engineered to express an agonist of a co-stimulatory signal of an immune cell and compositions comprising such viruses. Also described herein are chimeric Newcastle disease viruses engineered to express an antagonist of an inhibitory signal of an immune cell and compositions comprising such viruses. The chimeric Newcastle disease viruses and compositions are useful in the treatment of cancer. In addition, described herein are methods for treating cancer comprising administering Newcastle disease viruses in combination with an agonist of a co-stimulatory signal of an immune and/or an antagonist of an inhibitory signal of an immune cell.
申请公布号
EP2968525(A4)
申请公布日期
2016.10.26
申请号
EP20140774247
申请日期
2014.03.04
申请人
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI;MEMORIAL SLOAN KETTERING CANCER CENTER
发明人
PALESE, PETER;GARCIA-SASTRE, ADOLFO;ZAMARIN, DMITRIY;ALLISON, JAMES;WOLCHOK, JEDD, D.