PREPARATION METHOD FOR POLYMORPHIC 6-(4-CHLOROPHENOXY)-TETRAZOLO[5,1-A]PHTHALAZINE AND USE THEREOF

摘要

The present invention discloses processes for preparing polymorphic forms of 6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine, and use thereof. Those novel crystalline forms were fully characterized by using X-ray powder diffraction, thermogravimetric analysis, differential scanning calorimetry, Infrared spectroscopy, Raman spectroscopy, hygroscopicity analysis, and etc. The four novel crystalline forms were compared in terms of their stability, hygroscopicity and solubility, providing reference for the selection of the most preferred solid state of 6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine to be used for drug development. The processes for preparing the novel crystalline forms of 6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine of the present invention are simple, easy to control, and have excellent reproducibility, such that the desired crystal forms can be obtained steadily.