发明名称 |
NEW ANIMAL MODEL FOR DIABETIC COMPLICATIONS |
摘要 |
The invention relates to the surprising find that low density lipoprotein receptor-deficient mice (LDLr-/-) mice when fed with high energy diets produce controllable and consistent diabetic complications, especially renal damage, similar to the human pathophysiology and biological response. The invention thus comprises a method for discovering a preventive or therapeutic regimen for the prevention or treatment of diabetic micro- or macrovascular complications, comprising the steps of: a. feeding LDLr-/- mice, which have not been treated with streptozotocin, with a high energy diet; b. before, during and/or after this diet treating the mice with the preventive or therapeutic regimen; c. checking whether any change in the micro- or macrovascular system of the animal occurs. Specifically in such a method renal damage is assessed. Also use of said mice fed with a high energy diet for studying the diabetic micro- and macrovascular complications is part of the invention. |
申请公布号 |
EP2641091(B1) |
申请公布日期 |
2016.10.26 |
申请号 |
EP20110785153 |
申请日期 |
2011.11.14 |
申请人 |
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST- NATUURWETENSCHAPPELIJK ONDERZOEK TNO |
发明人 |
KLEEMANN, ROBERT;STOOP, REINOUT;VERHEIJEN, JOHAN, HENDRIKUS;WIELINGA, PETER, YDO;KOOISTRA, TEAKE |
分类号 |
G01N33/68 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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