发明名称 |
COMPOSITIONS AND METHODS FOR TREATING DISEASE USING SALMONELLA T3SS EFFECTOR PROTEIN (SIPA) |
摘要 |
The invention provides compositions and methods for reducing one or more symptoms of disease by administering compositions comprising SipA. The invention's compositions and methods are particularly advantageous in reducing symptoms of diseases that are associated with overexpression of P-gp and/or p53. The invention's compositions and methods are useful in reducing cancer symptom and/or cancer multidrug resistance (MDR). The invention provides a method for reducing one or more symptoms of cancer in a mammalian subject in need thereof, comprising administering to said subject a composition comprising purified SipA. In one embodiment, said SipA is operably conjugated to a nanoparticle. In another embodiment, said cancer comprises cancer cells resistant to at least one cytotoxin. |
申请公布号 |
EP3084445(A1) |
申请公布日期 |
2016.10.26 |
申请号 |
EP20140869581 |
申请日期 |
2014.12.11 |
申请人 |
UNIVERSITY OF MASSACHUSETTS |
发明人 |
MCCORMICK, BETH;MERCADO-LUBO, REGINO |
分类号 |
G01N33/574 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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