主权项 |
1. A compound of the formula or a pharmaceutically acceptable salt thereofwherein:
R1 is —C(O)R7; —C(O)OR7; —C(O)N(R11)(R12); —C(S)R7; —S(O)2R7; alkyl which is optionally substituted one or more times by halogen; cycloalkyl, which is optionally substituted one or more times by halogen, alkyl or haloalkyl; aryl optionally substituted one or more times by halogen, alkyl, haloalkyl, cycloalkyl, —OR7, —CN, —NR8R9—N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)OR7, —SO2N(R8)(R9), —N(R10)SO2—R7 or —S(O)m—R7; arylalkyl, wherein the aryl ring is optionally substituted one or more times by halogen, alkyl, haloalkyl, cycloalkyl, —OR7, —CN, —NR8R9—N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)OR7, —SO2N(R8)(R9), —N(R10)SO2—R7 or —S(O)m—R7; heteroaryl optionally substituted one or more times by halogen, alkyl, haloalkyl, cycloalkyl, —OR7, —CN, —NR8R9—N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)OR7, —SO2N(R8)(R9), —N(R10)SO2—R7 or —S(O)m—R7; or arylalkylcarbonyl, wherein the aryl ring is optionally substituted one or more times by halogen, alkyl, haloalkyl, cycloalkyl, —OR7, —CN, —NR8R9—N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)OR7, —SO2N(R8)(R9), —N(R10)SO2—R7 or —S(O)m—R7; R2 is H; halogen; —CN; —OR7; —N(R10)C(O)R7; —NR11R12; —C(O)R7; —C(O)N(R11)(R12); —N(R10)C(O)—R7; —C(O)OR7; —OC(O)R7; —SO2N(R11)(R12); —N(R10)SO2—R7; —S(O)m—R7; alkyl optionally substituted one or more times by halogen, —OR7, NR8R9, —CN, —N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)R7, —C(O)OR7, —OC(O)R7, —SO2N(R8)(R9), —N(R10)SO2—R7 or —S(O)m—R7; cycloalkyl optionally substituted one or more times by halogen, alkyl, haloalkyl, —OR7, —NR8R9, —CN, —N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)OR7, —SO2N(R8)(R9), —N(R10)SO2—R7 or —S(O)m—R7; heterocycloalkyl optionally substituted one or more times by halogen, alkyl, haloalkyl, —OR7, —CN, —NR8R9—N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)OR7, —SO2N(R8)(R9), —N(R10)SO2—R7 or —S(O)m—R7; aryl optionally substituted one or more times by halogen, alkyl, haloalkyl, cycloalkyl, —OR7, —CN, —NR8R9—N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)R7, —C(O)OR7, —OC(O)R7, —SO2N(R8)(R9), —N(R10)SO2—R7 or —S(O)m—R7; or heteroaryl optionally substituted one or more times by halogen, alkyl, haloalkyl, cycloalkyl, —OR7, —CN, —NR8R9, —N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)R7, —C(O)OR7, —OC(O)R7, —SO2N(R8)(R9), —N(R10)SO2—R7 or —S(O)m—R7; R3 is H; halogen; —CN; —OR7; —N(R10)C(O)R7; —NR11R12; —C(O)R7; —C(O)N(R11)(R12); —N(R10)C(O)—R7; —C(O)OR7; —OC(O)R7; —SO2N(R11)(R12); —N(R10)SO2—R7; —S(O)m—R7; alkyl optionally substituted one or more times by halogen, —OR7, NR8R9, —CN, —N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)R7, —C(O)OR7, —OC(O)R7, —SO2N(R8)(R9), —N(R10)SO2—R7 or —S(O)m—R7; cycloalkyl optionally substituted one or more times by halogen, alkyl, haloalkyl, —OR7, —NR8R9, —CN, —N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)OR7, —SO2N(R8)(R9), —N(R10)SO2—R7 or —S(O)m—R7; heterocycloalkyl optionally substituted one or more times by halogen, alkyl, haloalkyl, —OR7, —CN, —NR8R9—N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)OR7, —SO2N(R8)(R9), —N(R10)SO2—R7 or —S(O)m—R7; aryl optionally substituted one or more times by halogen, alkyl, haloalkyl, cycloalkyl, —OR7, —CN, —NR8R9—N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)R7, —C(O)OR7, —OC(O)R7, —SO2N(R8)(R9), —N(R10)SO2—R7 or —S(O)m—R7; or heteroaryl optionally substituted one or more times by halogen, alkyl, haloalkyl, cycloalkyl, —OR7, —CN, —NR8R9, —N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)R7, —C(O)OR7, —OC(O)R7, —SO2N(R8)(R9), —N(R10)SO2—R7 or —S(O)m—R7; R4 is H; halogen; —CN; alkyl optionally substituted one or more times by halogen or cycloalkyl optionally substituted once or twice by alkyl or halogen; or cycloalkyl optionally substituted once or twice by alkyl or halogen; R5 is H; halogen; —CN; alkyl optionally substituted one or more times by halogen or cycloalkyl optionally substituted once or twice by alkyl or halogen; or cycloalkyl optionally substituted once or twice by alkyl or halogen; R6 is H; halogen; —CN; alkyl optionally substituted one or more times by halogen or cycloalkyl optionally substituted once or twice by alkyl or halogen; or cycloalkyl optionally substituted once or twice by alkyl or halogen; R7 is independently H; alkyl optionally substituted one or more times by halogen, —OR10, —NR8R9, —CN, —N(R10)C(O)R10, —C(O)N(R8)(R9), —C(O)R10, —C(O)OR10 or —S(O)m—R10; cycloalkyl optionally substituted one or more times by halogen, alkyl, haloalkyl, —OR10, —NR8R9, —CN, —N(R10)C(O)R10, —C(O)N(R8)(R9), —C(O)OR10 or —S(O)m—R10; aryl optionally substituted one or more times by halogen, alkyl, haloalkyl, cycloalkyl, —OR10, —NR8R9, —CN, —N(R10)C(O)R10, —C(O)N(R8)(R9), —C(O)R10, —C(O)OR10—OC(O)R10, or —S(O)m—R10; or heteroaryl optionally substituted one or more times by halogen, alkyl, haloalkyl, cycloalkyl, —OR10, —NR8R9, —CN, —N(R9)C(O)R10—C(O)R10, —C(O)OR10—OC(O)R10 or —S(O)m—R10; R8 is independently H or alkyl; R9 is independently H or alkyl;
or R8 and R9 are joined together with the nitrogen to which they are attached form a saturated 5- to 7-membered heterocyclic ring; R10 is independently H, alkyl or haloalkyl; R11 is independently H; alkyl optionally substituted one or more times by halogen, —OR7, —NR8R9, —CN, —N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)R7, —C(O)OR7 or —S(O)m—R7; cycloalkyl optionally substituted one or more times by halogen, alkyl, haloalkyl, —OR7, —NR8R9, —CN, —N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)OR8 or —S(O)m—R8; aryl optionally substituted one or more times by halogen, alkyl, haloalkyl, cycloalkyl, —OR7, —CN, —NR8R9—N(R10)C(O)(R7), —C(O)N(R7)(R8), —C(O)R7, —C(O)OR7, —OC(O)R7 or —S(O)m—R7; heterocycloalkyl optionally substituted one or more times by halogen, alkyl, haloalkyl, —OR7, —CN, —NR8R9—N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)R7, —C(O)OR7, —OC(O)R7 or —S(O)m—R7; or heteroaryl optionally substituted one or more times by halogen, alkyl, haloalkyl, cycloalkyl, —OR7, —CN, —NR8R9, —N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)R7, —C(O)OR7, —OC(O)R7 or —S(O)m—R7; R12 is independently H; alkyl optionally substituted one or more times by halogen, —OR7, —NR8R9, —CN, —N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)R7, —C(O)OR7 or —S(O)m—R7; cycloalkyl optionally substituted one or more times by halogen, alkyl, haloalkyl, —OR7, —NR8R9, —CN, —N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)OR8 or —S(O)m—R8; aryl optionally substituted one or more times by halogen, alkyl, haloalkyl, cycloalkyl, —OR7, —CN, —NR8R9—N(R10)C(O)(R7), —C(O)N(R7)(R8), —C(O)R7, —C(O)OR7, —OC(O)R7 or —S(O)m—R7; heterocycloalkyl optionally substituted one or more times by halogen, alkyl, haloalkyl, —OR7, —CN, —NR8R9—N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)R7, —C(O)OR7, —OC(O)R7 or —S(O)m—R7; or heteroaryl optionally substituted one or more times by halogen, alkyl, haloalkyl, cycloalkyl, —OR7, —CN, —NR8R9, —N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)R7, —C(O)OR7, —OC(O)R7 or —S(O)m—R7;
or R11 and R12 are joined together with the nitrogen to which they are attached form a saturated 5- to 7-membered heterocyclic ring; R13 and R14 are joined together to form a 5-7 membered carbocyclic or heterocyclic ring that is fused to the pyridyl ring to which R13 and R14 are attached, wherein the ring formed by R13 and R14 is optionally substituted by 1 to 3 R15; R15 is independently H; halogen; —CN; —OR7; —C(O)N(R8)(R9); —C(O)R7; —C(O)OR7; —OC(O)R7; —SO2N(R8)(R9); —N(R10)SO2—R7; —S(O)m—R7; alkyl optionally substituted one or more times by halogen, —OR7, —NR8R9, —CN, —N(R11)C(O)R7, —C(O)N(R8)(R9), —C(O)R7, —C(O)OR7, —OC(O)R7, —SO2N(R8)(R9), —N(R10)S(O)2—R7, or —S(O)m—R7; cycloalkyl optionally substituted one or more times by halogen, alkyl, haloalkyl, —OR7, —NR8R9, —CN, —N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)OR8, —SO2N(R8)(R9), —N(R10)SO2—R7 or —S(O)m—R7; aryl optionally substituted one or more times by halogen, alkyl, haloalkyl, cycloalkyl, —OR7, —CN, —NR8R9, —N(R10)C(O)(R7), —C(O)N(R8)(R9), —C(O)R7—C(O)OR7, —OC(O)R7, —SO2N(R8)(R9), —N(R10)SO2—R7, or —S(O)m—R7; heterocycloalkyl optionally substituted one or more times by halogen, alkyl, haloalkyl, cycloalkyl, —OR7, —CN, —NR8R9, —N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)R7, —C(O)OR7, —OC(O)R7, —SO2N(R8)(R9), —N(R10)SO2—R7 or —S(O)m—R7; or heteroaryl optionally substituted one or more times by halogen, alkyl, haloalkyl, cycloalkyl, —OR7, —CN, —NR8R9, —N(R10)C(O)R7, —C(O)N(R8)(R9), —C(O)R7, —C(O)OR7, —OC(O)R7, —SO2N(R8)(R9), —N(R10)SO2—R7 or —S(O)m—R7; is a single or double bond; and m is 0, 1 or 2; provided that when R1 is benzyl or —C(O)alkyl, R5, R6 R13 and R14 cannot all be hydrogen at the same time and further provided that monocyclic heteroaryl cannot be a tetrazole ring. |