COMPOSITIONS AND METHODS FOR PREVENTING TUMOR GROWTH AND TREATING CANCER BY TARGETING LECTIN GALACTOSIDE-BINDING SOLUBLE 3 BINDING PROTEIN

摘要

The present invention discloses a method of treating, preventing or ameliorating tumor growth by immune response modulation via targeting LGALS3BP - CD33 related Siglec pathway using antibody or antibody-drug conjugate therapy. The present invention also provide use of anti-LGALS3BP antibody in combination with an immune checkpoint inhibitor for enhancing, increasing, promoting, expressing, modulating desirable immune response for prevention and treatment of tumors and metastases thereof. Also provides combination therapy with an immune checkpoint inhibitor.