发明名称 |
LEUKOTOXIN E/D AS A NEW ANTI-INFLAMMATORY AGENT AND MICROBICIDE |
摘要 |
The present invention relates to methods for preventing or treating Human Immunodeficiency Virus (HIV) infection, inflammatory conditions, and graft-versus-host-disease (GVHD) in a subject. Therapeutic compositions of the present invention comprise Leukocidin E (LukE) and/or D proteins or polypeptides. The invention further relates to methods of treating Staphylococcus aureus infection by administering a composition comprising a CCR5 antagonist or any molecule that blocks LukE/D interaction with CCR5+ cells in an amount effective to treat the S. aureus infection in the subject. |
申请公布号 |
EP2720754(B1) |
申请公布日期 |
2016.10.19 |
申请号 |
EP20120802525 |
申请日期 |
2012.06.19 |
申请人 |
NEW YORK UNIVERSITY |
发明人 |
TORRES, VICTOR, J.;UNUTMAZ, DERYA;ALONZO, FRANCIS |
分类号 |
A61P31/18;A61K31/41;A61K31/495;A61K38/16;A61K39/395;A61K45/06;A61P29/00;A61P31/00;A61P31/04 |
主分类号 |
A61P31/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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