发明名称 |
FUSED IMIDAZOLE AND PYRAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY |
摘要 |
A series of substituted benzimidazole, imidazo[1,2-α]pyridine and pyrazolo[1,5- α]pyridine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. |
申请公布号 |
EP3080120(A1) |
申请公布日期 |
2016.10.19 |
申请号 |
EP20140812175 |
申请日期 |
2014.12.08 |
申请人 |
UCB BIOPHARMA SPRL |
发明人 |
BROWN, JULIEN ALISTAIR;CALMIANO, MARK DANIEL;JONES, ELIZABETH PEARL;KROEPLIEN, BORIS;REUBERSON, JAMES THOMAS;SELBY, MATTHEW DUNCAN;SHAW, MICHAEL ALAN;ZHU, ZHAONING |
分类号 |
C07D471/04;A61K31/437;A61P29/00 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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地址 |
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