| 摘要 |
Anti-CD73 binding molecules, e.g., antibodies and antigen binding fragments thereof, comprising defined VL, VH and framework regions. Also provided are pharmaceutical formulations comprising the disclosed binding molecules, and methods for the diagnosis and treatment of diseases associated with CD73-expression, e.g., cancer. Such diseases can be treated by direct therapy with the anti-CD73 binding molecules disclosed herein (e.g., naked antibodies or antibody-drug conjugates that bind CD73), by adjuvant therapy with other antigen-binding anticancer agents such as immune checkpoint inhibitors (e.g., anti-CTLA-4 and anti-PD-1 monoclonal antibodies), and/or by combination therapies where the anti-CD73 molecules are administered before, after, or concurrently with chemotherapy. |
