发明名称 |
METHOD OF TREATMENT AND BIOASSAY INVOLVING MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) AS CARDIAC-DERIVED MYOCARDIAL DEPRESSANT FACTOR |
摘要 |
An embodiment of the present invention relates to a pharmaceutical composition, which includes a therapeutically effective amount of at least one anti-MIF antibody; and at least on pharmaceutically acceptable carrier. Another embodiment of the present invention relates to a pharmaceutical composition, which includes a therapeutically effective amount of at least one anti-CD74 antibody; and at least one pharmaceutically acceptable carrier. Another embodiment of the present invention relates to a pharmaceutical composition, which includes a therapeutically effective amount of at least one anti-TNFR antibody; a therapeutically effective amount of at least one anti-MIF antibody; and at least one pharmaceutically acceptable carrier. Other embodiments of the present invention relate to methods of treating or preventing cardiac dysfunction, cardiodepression, burn injury-associated cardiac dysfunction, improving cardiac function in a subject following acute myocardial infarction and identifying an MIF inhibitor. |
申请公布号 |
EP3078386(A2) |
申请公布日期 |
2016.10.12 |
申请号 |
EP20160170803 |
申请日期 |
2004.08.30 |
申请人 |
BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE SA;BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
Giroir, Brett;Willis, Monte;De la Cruz, Vidal;Sielecki, Thais |
分类号 |
A61K39/395;A61K;A61K39/00;C07K16/24;C07K16/28 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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