INDUCTION DOSING REGIMEN FOR THE TREATMENT OF TNF ALPHA MEDIATED DISORDERS

摘要

The invention relates to a multiple-variable dose method for treating a disorder in which TNF± activity is detrimental, comprising administering to a subject in need thereof a first induction dose of an anti-TNF± antibody which ranges from 161 to 320 mg such that a threshold level of TNF± inhibitor is achieved within an induction phase; and subsequently administering to the subject at least one treatment dose of the TNF± inhibitor within a treatment phase, such that treatment occurs