PURIFICATION OF TENOFOVIR ALAFENAMIDE AND ITS INTERMEDIATES

摘要

The present disclosure provides process for the purification of 9-{(R)-2-[((R,S)-{[(S)-l- (isopropoxycarbonyl)ethyl]amino} phenoxyphosphinyl) methoxy] propyl}adenine using acids to give enantiomerically pure tenofovir alafenamide.