METHODS AND COMPOSITIONS FOR TREATING BLEEDING DISORDERS
摘要
The present invention provides immune conjugates for inducing antigen specific immune tolerance to coagulation Factor VIII. The immune conjugates contain a FVIII protein or antigenic fragment that is conjugated to a binding moiety for a sialic acid binding Ig-like lectin (Siglec) expressed on B cells. The invention also provides methods of using the FVIII immune conjugates to induce immune tolerance to FVIII in a subject. Additionally provided in the invention are methods for treating bleeding disorders such as hemophilia A via the use of the FVIII immune conjugates and an unconjugated FVIII with coagulating activity.
申请公布号
EP2989123(A4)
申请公布日期
2016.10.12
申请号
EP20140788399
申请日期
2014.04.18
申请人
THE SCRIPPS RESEARCH INSTITUTE;PAULSON, JAMES, C.;MACAULEY, MATTHEW;PFRENGLE, FABIAN