发明名称 |
POLYCARBONATES BEARING AROMATIC N-HETEROCYCLES FOR DRUG DELIVERY |
摘要 |
Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug. |
申请公布号 |
EP3076955(A1) |
申请公布日期 |
2016.10.12 |
申请号 |
EP20140868495 |
申请日期 |
2014.12.03 |
申请人 |
INTERNATIONAL BUSINESS MACHINES CORPORATION;AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH;UNIVERSIDAD DEL PAIS VASCO-EUSKAL HERRIKO UNIBERTSITATEA |
发明人 |
CHAN, JULIAN M.W.;ENGLER, AMANDA C.;HEDRICK, JAMES L.;KE, XIYU;NG, VICTOR W.L.;SARDON, HARIZ;TAN, JEREMY P.K.;YANG, YI YAN |
分类号 |
A61K9/51;A61K31/704;A61K31/7088;A61K38/00;A61K47/34;C08G64/16 |
主分类号 |
A61K9/51 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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