| 摘要 |
Each electrode pair in a nucleic acid detection apparatus includes a first electrode, a second electrode, an insulator between the first electrode and the second electrode, and at least one bridge between the first electrode and the second electrode across the insulator. The insulator includes a channel providing a gap between the first electrode and second electrode. The bridge includes at least one nucleic acid strand having a sequence complementary to a target nucleic acid sequence. In some embodiments, the bridge includes a first nucleic acid strand permanently attached to the first electrode, a conductive linker permanently attached to the first nucleic acid, and a second nucleic acid strand permanently attached to the conductive linker and to the second electrode. In some embodiments, the bridge is made of non-nucleic acid conducting material upon which strands of nucleic acids are permanently bound as tethers along the length of the bridge. |
