发明名称 |
USE OF GLUCOCORTICOID RECEPTOR ANTAGONISTS IN COMBINATION WITH GLUCOCORTICOIDS TO TREAT ADRENAL INSUFFICIENCY |
摘要 |
This invention provides for a method of treating secondary adrenal insufficiency by co-administrating therapeutically effective amounts of a glucocorticoid and a glucocorticoid receptor antagonist to the patient in need thereof. In some embodiments, the method includes the proviso that the patient not be otherwise in need of treatment with a glucocorticoid and a glucocorticoid receptor antagonist. The treatment method can increase the patient's morning or basal cortisol level to at least about 12 µg/dL or a standard control level, and in turn, expedite significantly the recovery of the HPA axis. The method provided herein can improve health outcomes and life-threatening complications associated with secondary adrenal insufficiency. |
申请公布号 |
WO2016160969(A1) |
申请公布日期 |
2016.10.06 |
申请号 |
WO2016US24981 |
申请日期 |
2016.03.30 |
申请人 |
CORCEPT THERAPEUTICS, INC. |
发明人 |
MORAITIS, Andreas G.;COHAN, Pejman;BELANOFF, Joseph K. |
分类号 |
A61K31/496;A61K31/5375;A61K31/5377 |
主分类号 |
A61K31/496 |
代理机构 |
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