发明名称 |
PROCESS FOR THE MANUFACTURE OF AN AMINO ESTER |
摘要 |
Process for the manufacture of an amino ester of formula (I) R1—O—C(O)—(CH2)n—NH2 (I) in which n is an integer from 10 to 15 from an unsaturated ester responding to formula (II) R1—O—C(O)—(CH2)m—CH═CH—R2 (II) in which R1 is either H or a saturated alkyl group containing from 1 to 5 carbon atoms; R2 is either H or an alkyl group containing from 1 to 10 carbon atoms, either saturated or containing 1 or 2 unsaturations and bearing optionally a hydroxyl, a carboxylic or an ester group, and m is equal to 7, 8, 9, 10 or 11; said process comprising: submitting the unsaturated ester of formula (II) to a catalytic cross-metathesis reaction with a pentenenitrile chosen among 2-pentenenitrile or 3-pentenenitrile in order to obtain a ester-nitrile responding to formula (III) R1—O—C(O)—(CH2)m—CH═CH—(CH2)p—CN (III) in which m is equal to 7, 8, 9, 10 or 11 and p is equal to 0 or 1, and submitting the obtained ester-nitrile of formula (III) to an hydrogenation in order to obtain the amino ester of formula (I). |
申请公布号 |
US2016289167(A1) |
申请公布日期 |
2016.10.06 |
申请号 |
US201415037446 |
申请日期 |
2014.11.18 |
申请人 |
RHODIA OPERATIONS |
发明人 |
MARION Philippe;MORVAN Didier |
分类号 |
C07C227/04;C08G69/44;C07C253/30 |
主分类号 |
C07C227/04 |
代理机构 |
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代理人 |
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主权项 |
1. A process for the manufacture of an amino ester of formula (I)
R1—O—C(O)—(CH2)n—NH2 (I)in which n is an integer from 10 to 15from an unsaturated ester corresponding to formula (II)
R1—O—C(O)—(CH2)m—CH═CH—R2 (II) in which R1 is either H or a saturated alkyl group containing from 1 to 5 carbon atoms; R2 is either H or an alkyl group containing from 1 to 10 carbon atoms, either saturated or containing 1 or 2 unsaturations and bearing optionally a hydroxyl, a carboxylic or an ester group, and m is equal to 7, 8, 9, 10 or 11; said process comprising submitting the unsaturated ester of formula (II) to a catalytic cross-metathesis reaction with 2-pentenenitrile or 3-pentenenitrile in order to obtain a ester-nitrile responding to formula (III)
R1—O—C(O)—(CH2)m—CH═CH—(CH2)p—CN (III) in which m is equal to 7, 8, 9, 10 or 11 and p is equal to 0 or 1, and submitting the obtained ester-nitrile of formula (III) to an hydrogenation in order to obtain the amino ester of formula (I). |
地址 |
Paris FR |