METHOD FOR DELIVERY OF A BIOACTIVE SUBSTANCE NEAR/INTO A TARGET CELL

摘要

The present invention discloses a biocarrier for delivery of a bioactive substance near/into a target cell, comprising a bioactive substance-loaded core with a first electricity, and one or more block copolymer, each block copolymer comprising a zwitterionic block and an anchoring block with an initial electricity opposite to the first electricity, wherein the anchoring block binds to the core by electrostatic attraction, and the zwitterionic block extends outwardly to increase the biocarrier stability in mammalian blood. Additionally, the present invention also discloses a method of using the biocarrier.

主权项

1. A method for delivery of a bioactive substance near/into a target cell, comprising:
providing a bioactive substance-loaded core with a first electricity, wherein the core is embedded with a bioactive substance; providing one or more block copolymer, each block copolymer comprising a zwitterionic block and an anchoring block with an initial electricity opposite to the first electricity, wherein the anchoring block binds to the core by electrostatic attraction, the zwitterionic block extends outwardly, and a plurality of biocarriers are then self-assembled; injecting the biocarriers into mammalian blood, wherein the biocarriers are circulated to a specific region near the target cell; and performing an adjusting process to adjust the electricity of the anchoring block, so as to break the binding between the anchoring block and the core, the biocarrier is then disassembled to release the bioactive substance.