| 摘要 |
PROBLEM TO BE SOLVED: To provide stable pharmaceutical compositions for the oral delivery of enteric-coated bipolar trans carotenoid effective for treating diseases caused by hypoxia, such as ischemia, cancer, traumatic brain injury, respiratory disease, hemorrhagic shock, cardiovascular disease, multiple organ failure, atherosclerosis, myocardial infarction, emphysema and asthma.SOLUTION: A pharmaceutical composition for the oral delivery of a bipolar trans carotenoid salt contains i) a bipolar trans carotenoid salt, ii) cyclodextrin, and iii) a coating agent for preventing the conversion of a bipolar trans carotenoid salt into a cis-isomer under acidic conditions in mammalian stomach. Preferably, the coating agent is acrylate polymer. Preferably, the pharmaceutical composition is a tablet, pill, or capsule forms. The bipolar trans carotenoid salt is trance sodium crocetinate.SELECTED DRAWING: None |
