METHODS FOR PROGNOSING THE ABILITY OF A ZEARALENONE ANALOG COMPOUND TO TREAT CANCER

摘要

The instant invention provides methods of prognosing the ability of a zearalenone analog compound to treat a cancer in a subject, methods of prognosing the ability of a zearalenone analog compound to inhibit the growth of a cancer in a subject, and methods of prognosing the ability of a zearalenone analog compound to promote the activation of apoptosis of a cancer in a subject. Methods of treating a cancer in a subject are also provided. The invention also pertains to methods of determining whether a cancer in a subject is sensitive to treatment with a zearalenone analog compound.

主权项

1. A method of identifying a subject likely to respond to treatment with a zearalenone analog compound and treating a cancer in the subject so identified, the method comprising:
a) providing a sample derived from the subject; b) detecting whether said sample derived from said subject exhibits activated MAPK signaling as compared to a control sample; c) detecting whether said sample exhibits wild-type PI3K signaling as compared to a control sample; d) identifying said subject as likely to respond to treatment with a zearalenone analog compound when activated MAPK signaling and wild-type PI3K signaling is detected in said sample; and e) administering a therapeutically effective amount of the zearalenone analog compound to the subject identified in step (d).