发明名称 |
METHODS OF PRODUCING METHYL 4-AMINO-3-CHLORO-6-(4-CHLORO-2-FLUORO-3-METHOXYPHENYL)PYRIDINE-2-CARBOXYLATE |
摘要 |
Methods of producing methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate. One method comprises adding methyl isobutyl ketone to an aqueous solution comprising 4-chloro-2-fluoro-3-methoxyphenyl-boronic acid to form an organic phase comprising the 4-chloro-2-fluoro-3-methoxyphenylboronic acid and an aqueous phase. The organic phase and the aqueous phase are separated. The 4-chloro-2-fluoro-3-methoxyphenylboronic acid is reacted with methyl 4-(acetylamino)-3,6-dichloropyridine-2-carboxylate in methyl isobutyl ketone to produce methyl 4-(acetylamino)-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate, which is deacetylated to produce methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate. |
申请公布号 |
EP2797890(B1) |
申请公布日期 |
2016.10.05 |
申请号 |
EP20120862450 |
申请日期 |
2012.12.28 |
申请人 |
DOW AGROSCIENCES LLC |
发明人 |
OPPENHEIMER, JOSSIAN;EMONDS, MARK V.M.;DERSTINE, CHRISTOPHER W.;CLOUSE, ROBERT C. |
分类号 |
C07D213/803;C07F5/02 |
主分类号 |
C07D213/803 |
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