| 摘要 |
The present invention provides a method for preparing an entecavir formulation for oral administration, comprising the steps of: (A) micronizing entecavir into a particle size of 1-60 mum; (B) mixing the micronized entecavir and a pharmaceutical additive to form a pharmaceutical composition; and (C) compression molding the pharmaceutical composition by direct compression or dry granulation compression. It is possible to prepare a low dosage entecavir formulation for oral administration with excellent content uniformity and hepatitis B treatment effects through a simple process by the preparation method of the present invention. |
