发明名称 |
COMPOSITIONS AND METHODS FOR MODULATING AN IMMUNE RESPONSE |
摘要 |
Described herein are compositions for increasing IL-12 production comprising IgG or a fragment thereof or a variant thereof and uses of said compositions for treating cancer and infectious diseases. Also described herein are compositions for decreasing IL-12 production comprising an agent that inhibits signaling mediated by interaction between FcRn and IgG and uses of said compositions for treating autoimmune diseases. Further described herein are methods for assessing efficacy of treatment by monitoring levels of various cytokines in the subject. |
申请公布号 |
EP3074039(A2) |
申请公布日期 |
2016.10.05 |
申请号 |
EP20140866104 |
申请日期 |
2014.11.25 |
申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. |
发明人 |
BLUMBERG, RICHARD S.;BAKER, KRISTI;RATH, TIMO |
分类号 |
A61K39/395;A61K38/17;C07K16/28 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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