发明名称 |
MUTANT INTERLEUKIN-2 POLYPEPTIDES |
摘要 |
The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the ±-subunit of the IL-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof. |
申请公布号 |
EP3075745(A1) |
申请公布日期 |
2016.10.05 |
申请号 |
EP20160164244 |
申请日期 |
2012.02.07 |
申请人 |
ROCHE GLYCART AG |
发明人 |
AST, OLIVER;BRUENKER, PETER;FREIMOSER-GRUNDSCHOBER, ANNE;HERTER, SYLVIA;HOFER, THOMAS U.;HOSSE, RALF;KLEIN, CHRISTIAN;MOESSNER, EKKEHARD;NICOLINI, VALERIA G.;UMANA, PABLO |
分类号 |
C07K14/55;A61K38/20;A61K39/00;A61K39/395;A61K47/48;C07K14/54;C07K16/30;C07K16/40;C07K16/46;C07K19/00;C12N15/26 |
主分类号 |
C07K14/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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