发明名称 |
IDENTIFICATION OF TUMOR-PROTECTIVE EPITOPES FOR THE TREATMENT OF CANCERS |
摘要 |
Described herein are methods of identifying tumor-specific epitopes from the cancer tissue DNA of cancer patients using both DNA sequencing and bioinformatics techniques. The identification of tumor-specific epitopes provides pharmaceutical compositions with a limited number of tumor-specific peptides suitable for personalized genomics-driven immunotherapy of human cancer. Specifically disclosed herein is a novel index called the Differential Agretopic Index (DAI) for the epitope which allows prediction of whether immunization with a particular epitope will be protective against the tumor. Pharmaceutical compositions and methods of administration are also included. |
申请公布号 |
EP2901341(A4) |
申请公布日期 |
2016.10.05 |
申请号 |
EP20130840946 |
申请日期 |
2013.09.27 |
申请人 |
THE UNIVERSITY OF CONNECTICUT |
发明人 |
SRIVASTAVA, PRAMOD K.;MANDOIU, ION;DUAN, FEI |
分类号 |
G06F19/00;A61K38/00;A61K39/00;C12Q1/68;G01N33/573 |
主分类号 |
G06F19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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