发明名称 |
RECEPTOR-TARGETED NANOPARTICLES FOR ENHANCED TRANSCYTOSIS MEDIATED DRUG DELIVERY |
摘要 |
Receptor-targeted nanoparticles (R-NPs) are provided for selective transport into and through targeted tissues of therapeutic, prophylactic and diagnostic agents. R-NPs can include polymeric particle, lipid particles, inorganic particles, or a combination thereof with a targeting moiety selective for binding to a receptor on the cells where the agent is to be delivered, where the receptor mediates transcytosis of the nanoparticle into and through the cells. In a preferred embodiment, the targeting moiety is the neonatal Fc receptor. Examples demonstrate Fc-targeted nanoparticles which are actively transported across the intestinal epithelium, providing a route for the oral delivery of nanoparticle encapsulated active agents including peptides such as insulin. |
申请公布号 |
EP3074047(A2) |
申请公布日期 |
2016.10.05 |
申请号 |
EP20140812374 |
申请日期 |
2014.11.25 |
申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
PRIDGEN, ERIC, M.;ALEXIS, FRANK;FAROKHZAD, OMID, C.;LANGER, ROBERT, S.;BLUMBERG, RICHARD S. |
分类号 |
A61K47/48;A61P5/38 |
主分类号 |
A61K47/48 |
代理机构 |
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