METHODS FOR DIAGNOSING, SCREENING, IDENTIFYING, MONITORING, AND TREATING ADVERSE LOCAL TISSUE REACTIONS, WHICH LEAD TO FAILURE OF ORTHOPEDIC IMPLANTS

摘要

This invention relates to field of screening and diagnosing adverse local tissue reactions or ALTR using proteins and genes that are elevated in patients suffering from ALTR, even those with no symptoms. The early diagnosis of the ALTR can lead to its treatment and thus, the prevention of implant failure caused by the ALTR. The elevated proteins and genes are also the basis for treatment for ALTR and provide targets for drug development and basic research.

主权项

1. A kit for diagnosing, screening for, identifying, predicting and monitoring adverse local tissue reactions comprising a microarray comprising one or more nucleic acid probes in an ordered arrangement, reagents for isolating and/or purifying nucleic acids from biological tissue or bodily fluid, reagents for performing assays on the isolated and/or purified nucleic acid, instructions for use, and reference values, or the means or instructions for obtaining reference values in a sample, wherein the nucleic acid probes recognize least seven genes comprising:
CXCL9, CXCL10, IFNγ, IL6, IL8, CHIT1 and CCL18.