发明名称 |
NOVEL CYTOTOXIC AGENTS THAT PREFERENTIALLY TARGET LEUKEMIA INHIBITORY FACTOR (LIF) FOR THE TREATMENT OF MALIGNANCIES AND AS NEW CONTRACEPTIVE AGENTS |
摘要 |
Described herein are new anti-cancer compounds and methods of using such compounds, acting through a new mechanism of action by simultaneous inhibition of leukemia inhibitory factor (LIF) and MDM2. In one embodiment, a cytotoxic compound has the structure (I) or (II). In an embodiment, a method of treating cancer in a subject comprising administering to a subject a medicament comprising an effective amount of a cytotoxic small molecule compound that inhibits leukemia inhibitory factor or leukemia inhibitory factor receptor. |
申请公布号 |
WO2016154203(A1) |
申请公布日期 |
2016.09.29 |
申请号 |
WO2016US23582 |
申请日期 |
2016.03.22 |
申请人 |
EVESTRA, INC. |
发明人 |
NAIR, Hareesh;SANTHAMMA, Bindu;NICKISCH, Klaus |
分类号 |
A61K38/17;C07J3/00;C07J41/00;C07J51/00;G01N33/574 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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