AN IMPROVED PROCESS FOR THE PREPARATION OF PAZOPANIB OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

摘要

The present invention is relates to an improved process for the preparation of pazopanib or a pharmaceutically acceptable salts thereof. The present invention also relates to novel polymorphic Forms of pazopanib hydrochloride, and its intermediates thereof.

主权项

1: An improved process for preparation of pazopanib or a pharmaceutically acceptable salt thereof of Formula I,comprising:
a) reacting a compound of Formula A with a compound of Formula B in a solvent (S1) in presence of a base (B1) to obtain a compound of Formula II, b) reacting the obtained compound of Formula II with a methylating agent in a solvent (S2) in presence of a base (B2) to obtain a compound of Formula III, and c) condensing the compound of Formula II with Formula C in a solvent (S3) to obtain pazopanib or a pharmaceutically acceptable salts thereof wherein the base (B1) is selected from inorganic or organic base except sodium bicarbonate and the base (B2) is selected from inorganic or organic base except potassium carbonate or cesium carbonate.