RNA TRANSCRIPTION VECTOR AND USES THEREOF

摘要

The present invention relates to an improved RNA transcription vector, which is very suitable for the production of mRNA for in vivo therapeutic purposes. The improvements in the vector reside in the presence of a translation enhancer (TE) and a nuclear retention element (NRS), especially when the latter is the “Expression and Nuclear Retention Element” (ENE) of Kaposi's sarcoma associated Herpes virus (KSHV).

主权项

1. A nucleic acid vector comprising a translation enhancer (TE) sequence having at least 80% sequence identity to SEQ ID NO: 1, a transcribable nucleic acid sequence and a nuclear retention sequence represented by SEQ ID NO: 4.