发明名称 |
PSORALEN DERIVATIVES AS NON-PEPTIDIC INHIBITORS OF CHYMOTRYPSIN-LIKE ACTIVITY OF THE IMMUNOPROTEASOME |
摘要 |
This invention relates to new inhibitors of chymothrypsin-like activity of the immunoproteasome (inhibitors of β5ί or LMP7 subunit) with the general formula (I), where substituents are described in patent description. Compounds can be in the form of pure enantiomers or as racemic mixtures, or in the form of pharmaceutically acceptable salts. The present invention relates to the use of these inhibitors for the treatment of diseases where immunoproteasome activity is increased. |
申请公布号 |
WO2016151483(A1) |
申请公布日期 |
2016.09.29 |
申请号 |
WO2016IB51601 |
申请日期 |
2016.03.22 |
申请人 |
UNIVERZA V LJUBLJANI |
发明人 |
SOSIC, Izidor;GOBEC, Martina;BRUS, Boris;KNEZ, Damijan;OBREZA, Aleš;MLINARIC-RAŠCAN, Irena;GOBEC, Stanislav |
分类号 |
A61K31/37;A61K31/4025;A61P25/00;A61P29/00;A61P35/00 |
主分类号 |
A61K31/37 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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