PROCESS FOR THE SYNTHESIS OF 4-(3-METHANESULFONYLPHENYL)-1-N-PROPYL-PIPERIDINE
摘要
The present invention is directed to processes for the preparation of 4-(3-methanesulfonyl-phenyl)-1-N-propylpiperidine (I) or a pharmaceutically acceptable salt thereof, which comprises: oxidizing a sulfide of the formula (II): with a catalytic oxidizing agent and an oxidant; to give a compound of the formula (III): followed by catalytic reduction of the compound of formula (III).
申请公布号
EP1802573(B1)
申请公布日期
2016.09.28
申请号
EP20050793645
申请日期
2005.10.13
申请人
TEVA PHARMACEUTICALS INTERNATIONAL GMBH
发明人
GAUTHIER, DONALD, R.;DESMOND, RICHARD;DEVINE, PAUL, N.